MRI derived brain atrophy measures in Multiple Sclerosis
نویسندگان
چکیده
Purpose: To investigate whether MS atrophy can be assessed by SIENA and SIENAX software using other image types from MS research protocols than T1-weighted images without contrast agent, which are not always available. Method: We selected 46 MS patients with identical MRI protocols at two timepoints. We calculated normalized brain volume (NBV) using SIENAX, and percentage brain volume change (PBVC) using SIENA, from T1-weighted images with and without contrast agent, T2-weighted images, and (calculated) pseudo-T1-weighted images. Relative agreement of the results was assessed using variance component estimation. Results: Relative agreement with T1-weighted images without contrast agent was good for T1-weighted images with contrast agent (ICC=0.86 for NBV, ICC=0.77 for PBVC), and reasonably good for pseudo-T1 and T2-weighted images (T2: ICC=0.72 for NBV, 0.58 for PBVC; pseudoT1: ICC=0.68 for NBV, 0.83 for PBVC). Conclusion: Brain atrophy can be studied using SIENA and SIENAX if T1-weighted images without contrast agent are not available. T1weighted images with contrast agent should be used, if available. Otherwise, pseudo-T1 and T2-weighted images seem acceptable and accessible alternatives. The use of these other images will greatly improve research possibilities, especially regarding older datasets. 30 Methodological aspects of brain volume measurement
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